公司介绍

博上生物科技股份有限公司成立于2015年，位于浙江省海宁市，是一家专注于生物科技研发与生产的高新技术企业。

公司主要提供基因测序试剂与工具、荧光标记与染料产品、医药中间体原料、多肽与蛋白质合成试剂、核酸纯化与qPCR试剂、色谱分析试剂及实验室设备。

博上生物致力于为全球生物医药、科研机构和实验室提供高质量的创新产品和定制化技术解决方案，帮助客户在基因研究、药物开发和分子诊断等领域取得突破。

产品名称：5-0G488 酸

中文名称：5-0G488 酸

分子量：347.32

激发波长(nm)：498

发射波长(nm)：526

存储条件：密封、干燥处、2°C -8°C下保存

仅供科研使用。不可用于诊断程序。

产品描述：

5-OG488 酸是一种荧光染料。5-OG488酸与OregonGreen®488羧酸，5-异构体（OregonGreen®是Invitrogen的商标）是相同的分子。 这种化合物具有较高的光稳定性和较低的pKa~4.7，而5-FAM具有pKa~6.4。 5-OG488的pKa降低使其荧光在生理pH范围内基本上对pH不敏感。 该胺反应性5-OG488可用于制备亮绿色荧光生物共轭物，其激发/发射大值为~496 / 524nm。它是5-FITC的极好替代品。

参考文献：

Biodegradable polymersomes as carriers and release systems for paclitaxel using Oregon Green(R) 488 labeled paclitaxel as a model compound

Authors: Lee JS, Feijen J.

Journal: J Control Release (2012): 312

Microscopic imaging of intracellular calcium in live cells using lifetime-based ratiometric measurements of Oregon Green BAPTA-1

Authors: Lattarulo C, Thyssen D, Kuchibholta KV, Hyman BT, Bacskaiq BJ.

Journal: Methods Mol Biol (2011): 377

Pharmacokinetics of intraocular drug delivery of Oregon green 488-labeled triamcinolone by subtenon injection using ocular fluorophotometry in rabbit eyes

Authors: Lee SJ, Kim ES, Geroski DH, McCarey BE, Edelhauser HF.

Journal: Invest Ophthalmol Vis Sci (2008): 4506

Trans-scleral permeability of Oregon green 488

Authors: Lee SJ, Kim SJ, Kim ES, Geroski DH, McCarey BE, Edelhauser HF.

Journal: J Ocul Pharmacol Ther (2008): 579

A mismatch-selective bifunctional rhodium-Oregon Green conjugate: a fluorescent probe for mismatched DNA

Authors: Zeglis BM, Barton JK.

Journal: J Am Chem Soc (2006): 5654

The Pennsylvania Green Fluorophore: a hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes

Authors: Mottram LF, Boonyarattanakalin S, Kovel RE, Peterson BR.

Journal: Org Lett (2006): 581

Cetuximab-Oregon Green 488

Authors: Unknown

Journal: In: Molecular Imaging and Contrast Agent Database (MICAD), Bethesda (MD) (2004)

Collagen-binding adhesion protein 35-Oregon Green 488

Authors: Cheng KT, Van Zandvoort M.

Journal: In: Molecular Imaging and Contrast Agent Database (MICAD), Bethesda (MD). (2004)

Alexa and Oregon Green dyes as fluorescence anisotropy probes for measuring protein-protein and protein-nucleic acid interactions

Authors: Rusinova E, Tretyachenko-Ladokhina V, Vele OE, Senear DF, Alexander Ross JB.

Journal: Anal Biochem (2002): 18

Imaging of changes in sarcoplasmic reticulum [Ca(2+)] using Oregon Green BAPTA 5N and confocal laser scanning microscopy

Authors: White C, McGeown G.

Journal: Cell Calcium (2002): 151